Mapping the Evolution of Activity-Based Protein Profiling: A Bibliometric Review

Activity-based protein profiling (ABPP) is a chemoproteomic approach that employs small-molecule probes to directly evaluate functionality within complex proteomes. This technology has proven be potent strategy for mapping ligandable sites in organisms and significantly impacted drug discovery processes by enabling the development of highly selective inhibitors identification new therapeutic molecular targets. Despite being nearly quarter century old as tool, ABPP yet undergo bibliometric analysis. In order gauge its scholarly impact evolution, analysis was performed, comparing all 1,919 reported articles with published last five years. Through comprehensive data analysis, including 5-step workflow, most influential were identified, their parameters determined. The analyzed span from 1999 2022, providing overview historical current state research. presents, first time, characteristics articles, offering valuable insight into research conducted this field potential future directions. findings underscore crucial role novel target identification, well need continued advancements chemical proteomic technologies further expand utility ABPP.